Nexium 24HR Capsules, 42 Count


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The Nexium 24HR Difference

Finally. The Purple Pill is now available nationwide without a prescription for the treatment of frequent heartburn.

  • #1 doctor prescribed acid blocker brand*
  • Blocks acid at the source
  • Just one pill a day gives you all-day, all-night protection from frequent heartburn

* Based on IMS Health data: total NEXIUM prescription 2006-2013

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The Nexium 24HR Difference

Finally. The Purple Pill is now available nationwide without a prescription for the treatment of frequent heartburn.

  • #1 doctor prescribed acid blocker brand.*
  • Blocks acid at the source.
  • Just one pill a day gives you all-day, all-night protection from frequent heartburn.

* Based on IMS Health data: total NEXIUM prescription 2006-2013

The Nexium Legacy

  • Safe and Effective
    The active ingredient in Nexium 24HR has been safely and effectively prescribed to millions of people over the last 10 years.
  • Proven Science
    Nexium 24HR has been clinically proven to treat frequent heartburn.
  • Rx to OTC
    Nexium 24HR is one of the largest-selling prescription medications to become available over the counter.

How to Take Nexium 24HR

If you don’t wait around for your frequent heartburn to happen, then why should you wait to treat it? Start a Nexium 24HR regimen today and be protected from frequent heartburn.

  • Be Proactive — You know your body best, and if your frequent heartburn is getting in the way of living your life the way you want to, start treating it with Nexium 24HR.
  • Set a Schedule — As with any regimen, the biggest hurdle is just beginning. With just one pill a day, Nexium 24HR has made it easy to fit treating frequent heartburn into your schedule.

    So go on and give it an honest effort. Take one Nexium 24HR.

  • Know What to Expect — It may take 1-4 days for full effect. Nexium 24HR is clinically proven for the treatment of frequent heartburn and, like any medication, it’s important to use Nexium 24HR as directed.
  • Start Today — Nexium 24HR is available nationwide in stores and online without a prescription for frequent heartburn.

Types of Heartburn Treatments

There are three different over-the-counter medicines that treat heartburn PPIs (Nexium 24HR), H2s, and antacids. Each treats heartburn in a different way.


PPIs, like Nexium 24HR, treat heartburn by blocking the production of acid. PPIs may take 1-4 days for full effect, but relief lasts for 24 hours. PPIs are the only FDA-approved medications for over-the-counter treatment of frequent heartburn.

12HR H2s

H2s treat heartburn by blocking one of the signals that tell your body to produce acid. They start working within 30 minutes and their effects can last for up to 12 hours. However, if you use H2s for more than a few days in a row, they can become less effective at treating heartburn.


Antacids treat heartburn by neutralizing the acid in your stomach. They come in liquid and tablet forms. Antacids work quickly, but last for only 1-3 hours after use.

Tto Avoid Heartburn, Try the Following:

• Avoid certain foods that cause symptoms, such as rich, spicy, fatty and fried foods, chocolate, caffeine, carbonated beverages, alcohol, coffee, ketchup and mustard, mints, vinegar, tomato and citrus juices, and other acidic fruits and juices.


• Enjoy food in moderation. Check the nutritional labels on the foods you eat to make sure you’re portioning accurately. Smaller, slower and more frequent meals are better than three large meals a day.


• Be conscious of when you eat, avoid late-night snacks, and raise the head of your bed. Let gravity do its work.


• Get comfy. Belts and tight-fitting clothing may be fashionable, but they also put extra pressure on your stomach. That extra pressure can interfere with your body’s ability to keep acid in your stomach, where it belongs, and not cause heartburn.


• Keep tabs on yourself. Achieve and maintain a healthy weight. Track what and how you eat, your physical activity and any medicines you may be taking so you can learn your body’s heartburn triggers and avoid them in the future.

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Food and Other Triggers

Some common foods and beverages that might trigger heartburn include:

  • Rich, spicy, fried, or fatty foods
  • Chocolate
  • Caffeine
  • Carbonated beverages
  • Alcohol
  • Coffee
  • Ketchup and mustard
  • Vinegar
  • Tomato and citrus juices
  • Mints
  • Other acidic fruits and juices

Frequently Asked Questions

What is Nexium 24HR?
For adults (18 years and older) Nexium 24HR is indicated for the treatment of frequent heartburn (two or more days a week). The active ingredient in Nexium 24HR is esomeprazole 20 mg, which is a part of a group of medications called proton pump inhibitors, or PPIs.

What are proton pump inhibitors?
Proton pump inhibitors (PPIs) are a group of medications that stop heartburn at the source by turning off many of the pumps that produce acid.

What is heartburn and what does it feel like?
Heartburn is the burning sensation you feel when stomach acid flows into the esophagus. The pain often rises up through your chest and may spread toward your neck or throat.

How does Nexium 24HR treat frequent heartburn?
Cells in the lining of the stomach contain proton pumps that produce the acid your body uses during digestion. Heartburn can be caused when this stomach acid flows up into the esophagus. Nexium 24HR protects you from frequent heartburn by turning your acid pumps from on to off, reducing the amount of acid that rises into your esophagus and alleviating heartburn.

Is there a difference between Nexium 24HR and prescription NEXIUM?
The formulations of the 20mg OTC capsules (Nexium 24HR) and the prescription 20mg capsules (NEXIUM) contain the same medicine, esomeprazole, although there are differences in indications and directions for use. The 20mg NEXIUM capsule will continue to be available by prescription. Other dosages of NEXIUM will continue to be available by prescription only. Nexium 24HR is indicated for adults (18 years and older) with frequent heartburn — when you have heartburn two or more days a week — whereas prescription NEXIUM is indicated for many acid-related conditions.

Once available over-the-counter, can I stop taking my prescription heartburn medication and take Nexium 24HR?
You should not change or stop taking any prescriptions without first consulting with your doctor, pharmacist, or other health care professional. As always, it is important to discuss your frequent heartburn symptoms, lifestyle modifications (diet and exercise), and any acid-related conditions with your health care professional. He or she may help determine if Nexium 24HR is the right option to treat your frequent heartburn.

Will Nexium 24HR be covered by insurance plans?
Insurance coverage for over-the-counter medications may vary and will depend on your specific plan. Check with your insurance provider to find out if over-the-counter medications like Nexium 24HR are covered on your plan.

Where will Nexium 24HR be sold without a prescription?
In drug, grocery, mass merchandiser and club stores nationwide as well as through online retailers.

Will NEXIUM still be available by prescription?
Yes. All prescription NEXIUM indications and formulations will remain available with a prescription. However, Nexium 24HR will be available without a prescription for the treatment of frequent heartburn.

Where can I get more information about Nexium 24HR?
If you have questions, please call a customer service or speak to your doctor, pharmacist or other healthcare professional for any additional questions.

Will Nexium 24HR be safe to take with my other heartburn medications?
If you have questions about using Nexium 24HR at the same time as other medications, you should ask your physician or pharmacist before using. Always use Nexium 24HR as directed.

How many times a day will I have to use Nexium 24HR?
You should take Nexium 24HR once daily, for 14 days. Please use as directed.